Objective: To describe the use of clear aligners to achieve mandibular advancement in patients with retrognathic mandible. Materials and methods: Four patients, aged 9 and 10 years old, with a molar Angle class II relationship and canine class II relationships and with convex profile with retruded mandible are presented and discussed. The patients were in correspondence of the pubertal peak, so treatment plans included the advancement of the mandible to possibly stimulate mandibular growth. Due to the aesthetic concerns of the patients and their parents, it was decided to correct the malocclusion by only using clear aligners, without additional appliances. Results: The important correction of canine and molar relationships was achieved within 6 to 8 months of treatment. The perception of facial profile improvement was motivating for patients and helped to reinforce treatment compliance. Conclusions: The presentation of these case reports shows that the use of clear aligners in growing patients to correct canine and molar class II relationships with retruded mandibles is successful. Keywords: case report, class II, growing patient, Invisalign, mandibular advancement