Objective: To describe the use of clear aligners to achieve mandibular molar distalization in patients with molar Angle Class III relationship. Materials and methods: Two patients, aged 31 and 23 years old, with molar Angle Class III relationship and canine Class III relationship are presented and discussed. The patients were non-growing patients, so treatment plans included the distalization of mandibular molars. Due to the aesthetic concerns, it was decided to correct the malocclusion only with clear aligners, without additional appliances. Results: Although the patients were non-growing, distalization of mandibular molars was obtained and Angle molar and canine Class I relationships were achieved. The perception of facial profile improvement was very motivating for patients and it helped to reinforce treatment compliance. Conclusions: The presentation of these case reports shows that the use of clear aligners was reliable in non-growing patients to correct canine and molar Class III relationships. Keywords: Class III malocclusion, Invisalign, mandibular molar distalization, non-growing patients