The different treatment strategies for managing agenesis of permanent teeth depend on the individual skeletal and dental relationships, the practitioner‘s experience, and the latest developments in ­dental technologies. Simple and efficient biomechanical solutions and long-term observations are demonstrated using two treatment examples with orthodontic space closure for bilateral agenesis of maxillary lateral incisors and mandibular second premolars. Keywords: agenesis, orthodontic space closure, biomechanics, long-term retention