Deschner, James

Deutscher Zahnärztetag 2019

8. Nov 2019 — 9. Nov 2019Congress Center Messe Frankfurt

Speakers: Karl-Ludwig Ackermann, Sarah Al-Maawi, Kurt Werner Alt, Jassin Arnold, Thomas Attin, Mustafa Ayna, Anna Greta Barbe, Ingo Baresel, Jens Baresel, Tobias Bauer, Ursula Becker, Wilfried Beckmann, Christoph Benz, Lisa Bitterich, Dirk Bleiel, Uwe Blunck, Martin Boost, Andreas Braun, Anne Bredel-Geissler, Wolfgang Buchalla, Egon Burian, Sebastian Bürklein, Iain L. C. Chapple, Wolfgang Christian, Fabian Cieplik, Bettina Dannewitz, Monika Daubländer, Sybille David-Hebgen, Isabel Deckwer, James Deschner, Annika Döding, Christof Dörfer, Heike Dyrna, Norbert Engel, Peter Engel, Susanne Fath, Michael Frank, Roland Frankenberger, Rene Franzen, Cornelia Frese, Tobias Fretwurst, Michael Gahlert, Roland Garve, Werner Geurtsen, Shahram Ghanaati, Christiane Gleissner, Ulrike Gonder, Werner Götz, Dominik Groß, Knut A. Grötz, Martin Guffart, Norbert Gutknecht, Cornelius Haffner, Thorsten Halling, Frederic Hermann, Carlos Herrera-Vizcaino, Tim Hilgenfeld, Jürgen Hoffmann, Martin Hoffmann, Fabian Huettig, Alfons Hugger, Christine Hutschenreuter, Bruno Imhoff, Silke Jacker-Guhr, Søren Jepsen, A. Rainer Jordan, Alexander Jürchott, Bärbel Kahl-Nieke, Peer W. Kämmerer, Philipp Kanzow, Nele Kettler, Christian Kirschneck, Lydia Kogler, Bernd Kordaß, Franz-Josef Kramer, Norbert Krämer, Felix Krause, Matthis Krischel, Joachim Krois, Christina Kühne, Conrad Kühnöl, Bernd Lapatki, Silke Lehmann-Binder M.Sc., Christian Leonhardt, Ivona Leventic, Daniel Lindel, Jörg Alexander Lisson, Ulrike Lübbert, Elmar Ludwig, Anne-Katrin Lührs, Michael Lüpke, Frank Georg Mathers, Wibke Merten, Georg Meyer, Wolfram Misselwitz, Karin Mölling, Mhd Said Mourad, Dietmar Friedrich Müller, Moritz Mutschler, Katja Nickel, Nicole Nicklisch, Ina Nitschke, Olaf Oberhofer, Karina Obreja, Dietmar Oesterreich, Rebecca Otto, Simon Peroz, Peter Pospiech, Florian Probst, Monika Probst, Michael Rädel, Sven Reich, Katharina Reichenmiller, Katharina Reinecke, Daniel R. Reißmann, Bernd Reiss, Stefan Ries, Christiane Rinnen, Katharina Röher, Jerome Rotgans, Uwe Rudol, Michael Rumpf, Heidrun Schaaf, Claudia Schaller, Karina Schick, Ulrich Schiffner, Maximiliane Amelie Schlenz, Alexander Schmidt, Mathias Schmidt, Andrea-Maria Schmidt-Westhausen, Julian Schmoeckel, Wolfgang Schneider, Sigmar Schnutenhaus, Holger Schön, Andreas Schulte, Nelly Schulz-Weidner, Karola Schulze, Ralf Schulze, Falk Schwendicke, Thomas A. Schwenk, Andreas Simka, Ralf Smeets, Önder Solakoglu, David Sonntag, Hansmartin Spatzier, Benedikt Spies, Norbert Staab, Sabine Steding, Angela Stillhart, Marcus Stoetzer, Hendrik Terheyden, Andrea Thumeyer, Marin Vodanovic, Kai Voß, Maximilian Voß, Wolfgang Wahlster, Michael Walter, Sandra Weber, Almut Johanna Weigel, Paul Weigl, Michael Weiss, Hans-Jürgen Wenz, Johannes-Simon Wenzler, Christian Wesemann, Jens Westemeier, Lotta Westphal, Matthias Widbiller, Annette Wiegand, Horst Willeweit, Karl Frederick Wilms, Sandra Windecker, Michael M. Wolf, Anne Wolowski, Bernd Wöstmann, Sylvia Wuttig

Quintessenz Verlags-GmbH

Team-Journal, 4/2024

FachbeitragPages 210-215, Language: GermanTreib, Philipp / Treib, Johannes / Deschner, James

Neurologie, Geriatrie und Zahngesundheit

Die Belastung einer Gesellschaft durch Krankheiten wird als „Burden of disease“ bezeichnet. Neurologische Erkrankungen sind hier führend. Schlaganfall, Demenz, Epilepsie, MS, Parkinson, Polyneuropathie etc. führen für gewöhnlich nicht zum Tode, sondern ohne eine adäquate Behandlung zu einer progredienten Behinderung. Diese endet viel zu oft in einer sehr kostenintensiven Pflegebedürftigkeit.

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Oral Health and Preventive Dentistry, 1/2024

Open Access Online OnlyPeriodontologyDOI: 10.3290/j.ohpd.b5695264, PubMed ID (PMID): 3918951027. Aug 2024,Pages 417-424, Language: EnglishCores Ziskoven, Pablo / Nogueira, Andressa V. B. / Yoldaş, Onur / Buduneli, Nurcan / Wild, Philipp S. / Koeck, Thomas / Deschner, James

Apelin – A New Kid on the Block in Periodontology

Summary: Periodontitis is associated with numerous systemic diseases, and it has been shown that these associations are partly causal in nature. It is assumed that such interactions between periodontal and systemic diseases are also mediated via adipokines. Apelin, an adipokine about which there is little research in the dental field, is also produced together with its receptor in periodontal cells. The aim of this review was to summarize the currently available literature on the apelin-APJ system to better understand the pathomechanistic relationship between periodontitis and obesity and to determine the potential clinical relevance of apelin for diagnostics and therapy. In vitro studies suggest that apelin can enhance bacterial-induced synthesis of proinflammatory and proteolytic molecules, indicating a significant etiopathogenic role of this adipokine. Since serum levels of apelin are elevated in diabetes and/or obesity, it is possible that such systemic diseases promote the development and progression of periodontitis via apelin. On the other hand, it is also conceivable that apelin from the periodontium influences such systemic diseases. Further research is needed to better understand the role of apelin in the periodontium and the entire oral cavity, but also in the interactions between periodontal and systemic diseases. In particular, clinical intervention studies are needed to further decipher the etiopathogenic role of apelin in periodontitis. Keywords: apelin, adipocytokine, adipokine, periodontitis, periodontium

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Oral Health and Preventive Dentistry, 1/2024

Open Access Online OnlyOral HealthDOI: 10.3290/j.ohpd.b4997035, PubMed ID (PMID): 3837643520. Feb 2024,Pages 115-122, Language: EnglishWolf, Thomas Gerhard / Dianišková, Simona / Cavallé, Edoardo / Aliyeva, Rena / Cagetti, Maria-Grazia / Campus, Guglielmo / Deschner, James / Forna, Norina / Ilhan, Duygu / Mazevet, Marco / Lella, Anna / Melo, Paulo / Perlea, Paula / Rovera, Angela / Sculean, Anton / Sharkov, Nikolai / Slutsky, Ariel / Torres, António Roma / Saag, Mare

Dental Students’ and Dental School Graduates’ Practical Skills: An International Survey of Perceptions of National Dental Associations in Europe

Purpose: Dental students learn knowledge and practical skills to provide oral health care to the population. Practical skills must be maintained or continuously developed throughout a professional career. This cross-sectional survey aimed to evaluate the perception of practical skills of dental students and dental-school graduates by national dental associations (NDAs) in international comparison in the European Regional Organization of the FDI World Dental Federation (ERO-FDI) zone. Materials and Methods: A questionnaire of 14 items collected information on pre-/postgraduate areas. Results: A total of 25 countries participated (response rate: 69.4%), with 80.0% having minimum requirements for practical skills acquisition and 64.0% starting practical training in the 3rd year of study. In countries where clinical practical work on patients begins in the 2nd year of study, practical skills of graduates are perceived as average, starting in the 3rd year of study as mainly good, starting in the 4th as varying widely from poor to very good. In total, 76.0% of respondents feel that improvements are needed before entering dental practice. Improvements could be reached by treating more patients in dental school (32.0%), increasing the quantity of clinical training (20.0%), or having more clinical instructors (12.0%). In 56.0% of the countries, it is possible to open one’s own dental practice immediately after graduation, and in 16.0%, prior vocational training is mandatory. Conclusions: All participating countries in the ERO-FDI zone reported practical training in dental school, most starting in the 3rd year of study. The perception of practical skills of dental students and dental-school graduates among NDAs is very heterogeneous. Reasons for the perceived deficiencies should be further explored. Keywords: dental association, graduate, international, practical skills, student

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Oral Health and Preventive Dentistry, 1/2021

Open Access Online OnlyRandomised Controlled Clinical TrialDOI: 10.3290/j.ohpd.b2403649, PubMed ID (PMID): 348741428. Dec 2021,Pages 647-658, Language: EnglishEhlers, Vicky / Reuter, Ann Katrin / Kehl, Evan-Bengü / Enax, Joachim / Meyer, Frederic / Schlecht, Jennifer / Schmidtmann, Irene / Deschner, James

Efficacy of a Toothpaste Based on Microcrystalline Hydroxyapatite on Children with Hypersensitivity Caused by MIH: A Randomised Controlled Trial

Purpose: Hypersensitivity is a frequent complaint in children with molar incisor hypomineralisation (MIH). This double-blind randomised controlled trial aimed to evaluate non-inferiority in hypersensitivity relief of a toothpaste containing microcrystalline hydroxyapatite compared to amine fluoride in children with MIH. Materials and Methods: Children were randomised into 2 groups: either hydroxyapatite (intervention) or amine fluoride toothpaste (control). The primary endpoint was pain sensation in response to tactile stimulus (Wong-Baker FACES Pain Rating Scale) 56 days after randomisation and analysed by mixed effects linear regression analysis. Non-inferiority was inferred if the upper limit of the one-sided 95% confidence interval (CI) of the difference between intervention and control group was below the non-inferiority margin of 1 in the ITT (intention-to-treat) and PP (per protocol) population. Results: Twenty-one children were randomised and 14 children finished the study per protocol. In the ITT population, hydroxyapatite was non-inferior to amine fluoride (mean difference: -0.75 95%CI [-∞;0.49]). In the PP population, non-inferiority could not be shown (-0.62 [-∞;1.08]). Conclusions: Overall non-inferiority in hypersensitivity relief of a toothpaste containing hydroxyapatite compared to amine fluoride could not be shown. However, the hydroxyapatite group tended to be less hypersensitive in both populations. Attrition of the PP population due to the COVID-19 pandemic led to loss of statistical power. Keywords: children, hydroxyapatite, hypersensitivity, fluoride, molar incisor hypomineralisation (MIH)

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Team-Journal, 5/2015

Pages 271-274, Language: GermanDeschner, James

Wechselwirkungen zwischen Parodontitis und Erkrankungen des Gesamtorganismus

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Parodontologie, 4/2014

Pages 395-402, Language: GermanDeschner, James / Hagner, Martin

Rolle der Adipositas bei Entstehung und Progression von Parodontitis

Parodontitis ist eine chronische Erkrankung des Parodonts, die unbehandelt zu Zahnlockerung und Zahnausfall führen kann. Seit Längerem ist bekannt, dass Parodontitis in einem engen Zusammenhang mit Erkrankungen des Gesamtorganismus, zum Beispiel Diabetes mellitus und kardiovaskulären Erkrankungen, steht. Zahlreiche Studien belegen nun, dass Parodontitis auch mit Adipositas assoziiert ist. Die Wahrscheinlichkeit, an einer Parodontitis zu erkranken, ist bei Übergewichtigkeit um das 1,3-Fache und bei Adipositas um das 1,8-Fache erhöht, wie eine Meta-Analyse kürzlich zeigte. Außerdem scheint Adipositas die parodontale Heilung nach einer Parodontitistherapie negativ zu beeinflussen. Bisher ist noch weitgehend ungeklärt, ob es sich bei der Assoziation zwischen Adipositas und Parodontitis um eine kausale und/ oder non-kausale Beziehung handelt. Zahlreiche Pathomechanismen, die dieser Assoziation zugrunde liegen könnten, stehen derzeit im Fokus der parodontalen Forschung. Aufgrund der komplexen Interaktionen zwischen Parodontitis und Erkrankungen des Gesamtorganismus, kommt der interdisziplinären Zusammenarbeit eine herausragende Bedeutung zu. Keywords: Parodontitis, Parodontium, Adipositas, Adipokine

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The International Journal of Oral & Maxillofacial Implants, 6/2013

Online OnlyDOI: 10.11607/jomi.te27, PubMed ID (PMID): 24278945Pages 472-477, Language: EnglishDeschner, James / Nokhbehsaim, Marjan

Regulatory Effects of Inflammatory and Biomechanical Signals on Regenerative Periodontal Healing

Periodontitis is a chronic inflammatory disease associated with loss of periodontal attachment, collagen, and alveolar bone. Regeneration of periodontal tissues can be supported by the local application of enamel matrix derivative (EMD). However, periodontal regeneration remains a major and often unpredictable challenge as the result of a number of unknown factors. The authors' in vitro studies revealed that EMD stimulated the wound fill rate, proliferation, and adhesion of periodontal ligament (PDL) cells. However, in the presence of an inflammatory environment or biomechanical loading, the beneficial effects of EMD decreased significantly. EMD also stimulated the synthesis of growth factors and collagen, as well as calcium deposition, in PDL cell cultures. These beneficial effects of EMD on PDL cells were also significantly diminished by inflammation and biomechanical forces, respectively. The findings suggest that critical PDL cell functions pertinent to periodontal regeneration are reduced in an inflammatory environment and under biomechanical loading. Therefore, effective anti-infectious and anti-inflammatory periodontal treatment before the application of EMD may be critical to ensure the full regenerative capacity of the PDL tissue. Furthermore, occlusal loading of EMD-treated teeth, at least immediately following surgery, should be minimized to obtain optimal regenerative healing results. A better understanding of the interactions of growth factors and biomechanical signals will result in more powerful regenerative therapeutic strategies.

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Parodontologie, 4/2013

Pages 379-384, Language: GermanDeschner, James

Schmelzmatrixproteine

Molekulare und zelluläre Aspekte

Die Regeneration verlorengegangener parodontaler Gewebe kann durch die intraoperative Applikation von Schmelzmatrixproteinen (EMD) unterstützt werden. Insgesamt zeigen zahlreiche In-vitro-Studien, dass EMD die Proliferation, Adhäsion und Migration von parodontalen Ligament- (PDL)-Zellen fördert. EMD führt in diesen Zellen auch zu einer verstärkten Synthese von Wachstumsund Differenzierungsfaktoren, Matrixmolekülen und Osteogenese-assoziierten Faktoren, zu vermehrten Kalziumablagerungen sowie zu einer beschleunigten In-vitro-Wundheilung. Ähnliche positive Effekte übt EMD auch auf Osteoblasten bzw. osteoblastenartige Zellen, Zementoblasten und deren Vorläuferzellen aus. Mehrere Studien belegen zudem, dass EMD die Synthese von Entzündungsmediatoren hemmt, also antiinflammatorische Effekte ausübt. Lokale und systemische Faktoren könnten jedoch die regenerationsfördernden Effekte von EMD beeinflussen und sollten daher so gut wie möglich kontrolliert werden. Keywords: Schmelzmatrixderivat (EMD), Schmelzmatrixproteine, Amelogenin, Regeneration, Entzündung, parodontale Ligamentzellen

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Parodontologie, 3/2012

Pages 323, Language: GermanDeschner, James