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Prof. Dr. Dr. Hendrik Terheyden

Germany, Kassel

Prof Dr med dent Hendrik Terheyden is head physician at the Department of Oral and Maxillofacial Surgery, Helios Hospital in Kassel, Germany. Hendrik Terheyden studied dentistry from 1983 to 1989 at the University of Kiel. In 1989, he was a staff physician for the Navy in Flensburg. From 1989-1992 he studied human medicine at the University of Kiel. In 1993 he became a specialist in oral surgery and in 1997 a specialist in oral and maxillofacial surgery with the additional title of plastic surgery (1999). In 1999 he completed his PhD (Habilitation) at the University of Kiel. He received the Wassmund Prize of the German Society for Oral and Maxillofacial Surgery (DGMKG). In 2004, he became an adjunct professor at Kiel University. From 2009 to 2012, he was president of the German Society for Implantology, and from 2017 to 2019, he was Chairman of the Oral and Maxillofacial Surgery Working Group of the German Society for Oral and Maxillofacial Surgery (DGZMK). Since 2006, Prof Terheyden has been section editor of the International Journal of Oral & Maxillofacial Surgery, and since 2012 he has been editor in chief of the International Journal of Implant Dentistry. Since 2021, he has served on the board of the Working Group of Senior Hospitalists of the German Society for Oral and Maxillofacial Surgery.

Books

18 Products found

  
Reinhard Gruber / Bernd Stadlinger / Hendrik Terheyden (Editor)

Kommunikation der Zellen: Zellatlas – Visualisierte Biologie in der Oralen Medizin

Series: Cell-to-Cell Communication, Band 7
1st Edition 2022
Book
Hardcover, 21 x 29,7 cm, kostenfreie Augmented Reality App zum Kapitel "Osteoklasten/Odontoklasten", 264 pages, 298 illus
Language: German
Categories: General Dentistry, Human Medicine, Interdisciplinary, Student literature
ISBN 978-3-86867-588-7
QP Deutschland

Hendrik Terheyden

Augmentation Surgery

Biologic Principles | Surgical Techniques | Clinical Challenges

1st Edition 2022
Book
Hardcover, 21 x 28 cm, 408 pages, 1383 illus
Language: English
Categories: Implantology, Oral/Maxillofacial Surgery, Oral Surgery
Stock No.: BG146
ISBN 978-1-78698-113-4
QP Deutschland

$248.00
Reinhard Gruber / Bernd Stadlinger / Hendrik Terheyden (Editor)

Cell-to-Cell Communication: Cell-Atlas – Visual Biology in Oral Medicine

Series: Cell-to-Cell Communication, Volume 7
1st Edition 2022
Book
Hardcover, 21 x 29,7 cm, 244 pages, 298 illus
Language: English
Categories: General Dentistry, Human Medicine, Interdisciplinary
Stock No.: BG151
ISBN 978-1-78698-107-3
QP Deutschland

$108.00
Hendrik Terheyden

Augmentationschirurgie

Biologische Grundlagen, Operationstechniken, Klinische Herausforderungen

1. Auflage 2021
Book
Hardcover, 21 x 28 cm, 408 pages, 1383 illus
Language: German
Categories: Implantology, Oral/Maxillofacial Surgery, Oral Surgery, Student literature
ISBN 978-3-86867-548-1
QP Deutschland

Tord Berglundh / Søren Jepsen / Bernd Stadlinger / Hendrik Terheyden

Kommunikation der Zellen: Periimplantitis und ihre Prävention

Series: Cell-to-Cell Communication, Band 6
1. Auflage 2019
DVD
2 DVDs inkl. detailliertem Booklet im Hardcover
Language: German
Category: Implantology
ISBN 978-3-86867-404-0
QP Deutschland

Tord Berglundh / Søren Jepsen / Bernd Stadlinger / Hendrik Terheyden

Cell-to-Cell Communication: Peri-implantitis and its Prevention

Series: Cell-to-Cell Communication, Volume 6
1st Edition 2019
DVD
2 DVDs and a detailed booklet in hardcover; PAL/NTSC; 15 min
Language: English
Category: Implantology
Stock No.: C3033
ISBN 978-1-78698-021-2
QP Deutschland

$128.00
Bernd Stadlinger / Hendrik Terheyden

Kommunikation der Zellen: Die gesteuerte Knochenregeneration

Series: Cell-to-Cell Communication, Band 5
1. Auflage 2017
DVD
2 DVDs inkl. detailliertem Booklet im Hardcover
Language: German
Category: Implantology
ISBN 978-3-86867-341-8
QP Deutschland

Bernd Stadlinger / Hendrik Terheyden

Cell-to-Cell Communication: Guided Bone Regeneration

Series: Cell-to-Cell Communication, Volume 5
1st Edition 2016
DVD
2 DVDs and a detailed booklet in hardcover; PAL/NTSC; 15 min
Language: English
Category: Implantology
Stock No.: C3000
ISBN 978-1-78698-003-8
QP Deutschland

Product out of print.

out of print
Søren Jepsen / Mariano Sanz / Bernd Stadlinger / Hendrik Terheyden

Kommunikation der Zellen: Orale und systemische Gesundheit

Series: Cell-to-Cell Communication, Band 4
1. Auflage 2016
DVD
2 DVDs inkl. detailliertem Booklet im Hardcover
Language: German
Categories: Human Medicine, Interdisciplinary, Periodontics, General Dentistry
ISBN 978-3-86867-301-2
QP Deutschland

Bernd Stadlinger / Hendrik Terheyden

Cell-to-Cell Communication: Osseointegration

Series: Cell-to-Cell Communication, Volume 1
2nd Revised Edition 2016
DVD
2 DVDs and a detailed booklet in hardcover; PAL/NTSC; 12 min
Language: English
Categories: Human Medicine, Implantology, General Dentistry
Stock No.: C3001
ISBN 978-1-85097-295-2
QP Deutschland

$128.00
Søren Jepsen / Mariano Sanz / Bernd Stadlinger / Hendrik Terheyden

Cell-to-Cell Communication: Oral Health and General Health

The Links Between Periodontitis, Atherosclerosis, and Diabetes

Series: Cell-to-Cell Communication, Volume 4
1st Edition 2016
DVD
2 DVDs and a detailed booklet in a hardcover; NTSC/PAL, 40 pages, 55 illus
Language: English
Categories: Human Medicine, Interdisciplinary, Periodontics, General Dentistry
Stock No.: C3009
ISBN 978-1-85097-288-4
QP Deutschland

Product out of print.

out of print
Bernd Stadlinger / Hendrik Terheyden

Kommunikation der Zellen: Die Osseointegration

Series: Cell-to-Cell Communication, Band 1
3., überarbeitete Auflage 2016
DVD
2 DVDs inkl. detailliertem Booklet im Hardcover
Language: German
Categories: Human Medicine, Implantology, General Dentistry
ISBN 978-3-86867-306-7
QP Deutschland

Bernd Stadlinger / Hendrik Terheyden

Kommunikation der Zellen: Die parodontale Regeneration

Series: Cell-to-Cell Communication, Band 3
1. Auflage 2015
DVD
2 DVDs inkl. detailliertem Booklet im Hardcover
Language: German
Categories: Human Medicine, Periodontics
ISBN 978-3-86867-251-0
QP Deutschland

Bernd Stadlinger / Hendrik Terheyden

Cell-to-Cell Communication: Periodontal Regeneration

Series: Cell-to-Cell Communication, Volume 3
1st Edition 2015
DVD
2 DVDs and a detailed booklet in a hardcover; NTSC/PAL
Language: English
Categories: Human Medicine, Periodontics
Stock No.: C3008
ISBN 978-1-85097-280-8
QP Deutschland

$128.00
Stephen Chen / Daniel Buser / Daniel Wismeijer (Editor)
Luca Cordaro / Hendrik Terheyden

Alveolarkammaugmentationen bei Implantatpatienten

Ein zweizeitiges Konzept

Series: ITI Treatment Guide Series, Band 07
1. Auflage 2014
Book
Hardcover, 232 pages, 600 illus colored
Language: German
Category: Implantology
ISBN 978-3-86867-235-0
QP Deutschland

Bernd Stadlinger / Hendrik Terheyden

Cell-to-Cell Communication: Inflammatory Reactions

Series: Cell-to-Cell Communication, Volume 2
2nd Edition 2013
DVD
2 DVDs and a detailed booklet in a hardcover; NTSC/PAL
Language: English
Categories: Human Medicine, Periodontics
Stock No.: C3007
ISBN 978-1-85097-243-3
QP Deutschland

Product out of print.

out of print
Hiromasa Yoshie / Bernd Stadlinger / Hendrik Terheyden / Roland Frankenberger

Kommunikation der Zellen

Illustrierte Beiträge aus der zahnmedizinischen Forschung und Praxis

1. Auflage 2013
Book
Hardcover, 100 pages, 188 illus
Language: German
Categories: Periodontics, Science and Research, General Dentistry
ISBN 978-3-86867-167-4
QP Deutschland

Bernd Stadlinger / Hendrik Terheyden

Kommunikation der Zellen: Die entzündliche Reaktion

Series: Cell-to-Cell Communication, Band 2
1. Auflage 2013
DVD
2 DVDs inkl. detailliertem Booklet im Hardcover
Language: German
Categories: Human Medicine, Periodontics
ISBN 978-3-86867-140-7
QP Deutschland

Kommunikation der Zellen: Periimplantitis und ihre Prävention

Tord Berglundh / Søren Jepsen / Bernd Stadlinger / Hendrik Terheyden

Length: 16 minutes
Production year: 2019
Language: German, English
Series: Cell-to-Cell Communication
available since: February 18, 2019

Cell-to-Cell Communication: Peri-implantitis and its Prevention

Tord Berglundh / Søren Jepsen / Bernd Stadlinger / Hendrik Terheyden

Length: 16 minutes
Production year: 2019
Language: English, German
Series: Cell-to-Cell Communication
available since: February 14, 2019

free

Kommunikation der Zellen - Die Reihe (Trailer)

Bernd Stadlinger / Hendrik Terheyden

Length: 7 minutes
Production year: 2018
Language: German
Series: Cell-to-Cell Communication
available since: July 12, 2018

Kommunikation der Zellen: Die gesteuerte Knochenregeneration (Expert Version)

Bernd Stadlinger / Hendrik Terheyden

Length: 16 minutes
Production year: 2016
Language: German, English
Series: Cell-to-Cell Communication
available since: October 20, 2016

Cell-to-Cell Communication: Guided Bone Regeneration (Expert Version)

Bernd Stadlinger / Hendrik Terheyden

Length: 16 minutes
Production year: 2016
Language: English, German
Series: Cell-to-Cell Communication
available since: September 27, 2016

Kommunikation der Zellen: Die parodontale Regeneration

Bernd Stadlinger / Hendrik Terheyden

Length: 14 minutes
Production year: 2016
Language: German, English
Series: Dental Video Journal
Category: Periodontics
available since: August 8, 2016

Cell-to-Cell Communication: Periodontal Regeneration

Bernd Stadlinger / Hendrik Terheyden

Length: 14 minutes
Production year: 2016
Language: English, German
Series: Dental Video Journal
Category: Periodontics
available since: August 8, 2016

Kommunikation der Zellen: Orale und systemische Gesundheit (Expert Version)

Søren Jepsen / Mariano Sanz / Bernd Stadlinger / Hendrik Terheyden

Length: 17 minutes
Production year: 2016
Language: German, English
Series: Cell-to-Cell Communication
available since: February 19, 2016

Cell-to-Cell Communication: Oral Health and General Health (Expert Version)

Søren Jepsen / Mariano Sanz / Bernd Stadlinger / Hendrik Terheyden

Length: 17 minutes
Production year: 2016
Language: English, German
Series: Cell-to-Cell Communication
available since: February 12, 2016

Kommunikation der Zellen: Die parodontale Regeneration (Expert Version)

Bernd Stadlinger / Hendrik Terheyden

Length: 14 minutes
Production year: 2015
Language: German, English
Series: Cell-to-Cell Communication
Category: Periodontics
available since: March 5, 2015

Cell-to-Cell Communication: Periodontal Regeneration (Expert Version)

Bernd Stadlinger / Hendrik Terheyden

Length: 14 minutes
Production year: 2015
Language: English, German
Series: Cell-to-Cell Communication
Category: Periodontics
available since: March 5, 2015

Kommunikation der Zellen - Die entzündliche Reaktion

Bernd Stadlinger / Hendrik Terheyden

Length: 15 minutes
Production year: 2012
Language: German, English
Series: Dental Video Journal
Category: Periodontics
available since: January 10, 2014

Cell-to-Cell Communication - Inflammatory Reactions

Bernd Stadlinger / Hendrik Terheyden

Length: 15 minutes
Production year: 2012
Language: English, German
Series: Dental Video Journal
Category: Periodontics
available since: January 10, 2014

Kommunikation der Zellen - Die entzündliche Reaktion (Public Version)

Bernd Stadlinger / Hendrik Terheyden

Length: 13 minutes
Production year: 2012
Language: German
Series: Cell-to-Cell Communication
Category: Periodontics
available since: January 8, 2013

Kommunikation der Zellen: Die entzündliche Reaktion (Expert Version)

Bernd Stadlinger / Hendrik Terheyden

Length: 15 minutes
Production year: 2012
Language: German, English
Series: Cell-to-Cell Communication
Category: Periodontics
available since: January 8, 2013

Cell-to-Cell Communication: Inflammatory Reactions (Expert Version)

Bernd Stadlinger / Hendrik Terheyden

Length: 15 minutes
Production year: 2012
Language: English, German
Series: Cell-to-Cell Communication
Category: Periodontics
available since: October 3, 2012

Cell-to-Cell Communication: Osseointegration (Expert Version)

Bernd Stadlinger / Hendrik Terheyden

Length: 12 minutes
Production year: 2010
Language: English, German
Series: Cell-to-Cell Communication
Category: Implantology
available since: November 4, 2011

Cell-to-Cell Communication - Osseointegration

Bernd Stadlinger / Hendrik Terheyden

Length: 12 minutes
Production year: 2010
Language: English, German
Series: Dental Video Journal
Category: Implantology
available since: November 4, 2011

Kommunikation der Zellen: Die Osseointegration (Expert Version)

Bernd Stadlinger / Hendrik Terheyden

Length: 12 minutes
Production year: 2010
Language: German, English
Series: Cell-to-Cell Communication
Category: Implantology
available since: January 10, 2011

Kommunikation der Zellen - Die Osseointegration

Bernd Stadlinger / Hendrik Terheyden

Length: 12 minutes
Production year: 2010
Language: German, English
Series: Dental Video Journal
Category: Implantology
available since: January 10, 2011

Events

  
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31st EAO Annual Scientific Meeting

Details make perfectionOctober 24, 2024 — October 26, 2024MiCo - Milano Convention Centre, Milano, Italy
Speakers: Bilal Al-Nawas, Gil Alcoforado, Federico Hernández Alfaro, Sofia Aroca, Wael Att, Gustavo Avila-Ortiz, Kathrin Becker, Anne Benhamou, Juan Blanco Carrión, Dieter Bosshardt, Daniel Buser, Francesco Cairo, Paolo Casentini, Raffaele Cavalcanti, Tali Chackartchi, Renato Cocconi, Luca Cordaro, Luca De Stavola, Nuno Sousa Dias, Egon Euwe, Vincent Fehmer, Alberto Fonzar, Helena Francisco, Lukas Fürhauser, German O. Gallucci, Oscar Gonzalez-Martin, Dominik Groß, Robert Haas, Alexis Ioannidis, Simon Storgård Jensen, Ronald Jung, France Lambert, Luca Landi, Georg Mailath-Pokorny jun., Silvia Masiero, Iva Milinkovic, Carlo Monaco, Jose Nart, José M. Navarro, Katja Nelson, Manuel Nienkemper, David Nisand, Michael Payer, Sergio Piano, Bjarni E. Pjetursson, Sven Reich, Isabella Rocchietta, Giuseppe Romeo, Irena Sailer, Mariano Sanz, Ignacio Sanz Martín, Frank Schwarz, Shakeel Shahdad, Massimo Simion, Ralf Smeets, Benedikt Spies, Bogna Stawarczyk, Martina Stefanini, Hendrik Terheyden, Tiziano Testori, Daniel Thoma, Ana Torres Moneu, Piero Venezia, Lukas Waltenberger, Hom-Lay Wang, Stefan Wolfart, Giovanni Zucchelli, Otto Zuhr
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European Association for Osseintegration (EAO)

This author's journal articles

  
Deutsche Zahnärztliche Zeitschrift, 1/2023
NachrufPages 59-62, Language: GermanTerheyden, Hendrik / Wiltfang, Jörg

Nachruf für Prof. Dr. med. Dr. med. dent. Franz Hermann Härle

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Deutsche Zahnärztliche Zeitschrift, 3/2021
GesellschaftPages 190, Language: GermanTerheyden, Hendrik / Wolff, Klaus Dietrich / Raguse, Dirk / Kramer, Franz-Josef

Zum Tod von Prof. Bodo Hoffmeister: Kompetenz und Empathie kennzeichneten sein erfolgreiches Wirken in Wissenschaft und Praxis

Gemeinsamer Nachruf ehemaliger Kollegen und Schüler
Gemeinsamer Nachruf ehemaliger Kollegen und Schüler Kompetenz, Empathie und nie en¬dender Forschungsdrang – diese Attribute kennzeichneten ein beeindruckendes und erfolgreiches Leben für die Zahn-, Mund- und Kieferheilkunde in Deutschland und weit darüber hinaus: Am 24. Februar 2021 ist unser verehrter Lehrer, Kollege und Freund Prof. Dr. med. Dr. med. dent. Bodo Hoffmeister nach kurzer Krankheit mit 72 Jahren leider viel zu früh von uns gegangen.
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Quintessenz Zahnmedizin, 12/2020
Zahnmedizin allgemeinPages 1430-1435, Language: GermanTerheyden, Hendrik / Stadlinger, Bernd / Gruber, Reinhard

Osteoklasten als Zellen des Immunsystems

Osteoklasten wurden lange für mesenchymale Knochenzellen gehalten. Aber neue Kenntnisse aus der Entwicklungsbiologie hinsichtlich der molekularen Steuerung der Zelldifferenzierung und der Immunmodulation des Knochenabbaus weisen die Osteoklasten klar als Mitglieder des Immunsystems aus. Osteoklasten sind für viele zahnärztliche Therapien wie die geordnete Zahneruption und kiefer-orthopädische Zahnbewegung, den Umbau eines Knochentransplantates oder die Osseointegration eines Zahnimplantates unerlässlich. Die Bedeutung der Osteoklasten bei der oralen Immunabwehr wird insbesondere bei Dysfunktionen der Osteoklasten deutlich, so beispielsweise bei der medikamenten-assoziierten Kiefernekrose. Die Immunmodulation der Osteoklastogenese kann zu foudroyanten Verläufen bis hin zur eitrigen Entzündung führen, wofür die entzündliche Wurzelresorption und die Periimplantitis klinische Beispiele sind. Die Aufgabe des Zahnarztes in diesen Situationen ist die Minderung der Osteoklastogenese durch Reduktion der mikrobiellen Antigenbelastung durch endodontische Behandlung bzw. Kontrolle des Biofilmes. Die marginale Parodontitis kann der Osteoimmunologie als Modell zur Erforschung der entzündlichen Knochenresorptionen dienen. Hiervon profitieren im Gegenzug auch andere Fachbereiche wie z. B. die Rheumatologie. Keywords: Osteoklasten, Zelldifferenzierung, Osteoimmunologie, Wurzelresorption, Kiefernekrose, Zytokine
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2019-1
Pages 64-69, Language: EnglishStadlinger, Bernd / Jepsen, Søren / Terheyden, Hendrik / Heitz-Mayfield, Lisa J. A. / Berglundh, Tord

The Development of Peri-Implantitis and How to Prevent it: Promotion of a New Scientific Film in the Cell-to-Cell Communication Series

This complementary article was prepared by Bernd Stadlinger, Søren Jepsen and Hendrik Terheyden and presents an overview of the content of the 6th volume of the "Cell-to-Cell Communication" series. The 6th volume of the series entitled "Peri-implantitis and its prevention" was prepared by a collaborative team of authors - Tord Berglundh, Søren Jepsen, Bernd Stadlinger, Hendrik Terheyden - and an advisory board. This computer-animated scientific film was launched at the EuroPerio meeting in Amsterdam in June 2018, providing a novel way to visualize the complex processes of peri-implant inflammation. It visualizes the biological background of the development and progression of peri-implantitis and highlights the importance of the microbiome and host immune defense. In addition, a perspective article has recently been published in the leading implant journal Clinical Oral Implants Research (Berglundh et. al. 2019). It is hoped that this complementary article will bring the film to the attention of the many ITI Fellows and Members who enjoy reading Forum Implantologicum. Please look for the Q reader at the end of the article and enjoy this captivating film.
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Implantologie, 2/2018
Pages 115-122, Language: GermanTerheyden, Hendrik

Implantatversorgungen bei Kindern, Jugendlichen und jungen Erwachsenen

Indikation und Zeitpunkt
Anhand der beiden Parameter Infraokklusion und Implantatüberleben aus Literaturdaten werden in der vorliegenden Arbeit Empfehlungen zur Indikation und zum Zeitpunkt von Zahnimplantaten bei Kindern und Jugendlichen erarbeitet. Bei einer Implantation bei Kindern unter 12 Jahren ist im Schnitt mit ca. 14 bis 17 mm Infraokklusion (Maximum: 20-24 mm) und einem Implantatüberleben von 72 % zu rechnen. Bei Adoleszenten (12-18 Jahre) beträgt die Infraokklusion etwa 3 mm (Maximum: 8 mm) und die Implantatprognose 93 %. Bei jungen Erwachsenen (18-31 Jahre) wurde eine Infraokklusion anhand von Wachstumsstudien von 1,7 mm (Maximum: 6 mm) beobachtet bei einer Implantatprognose von 97,4 %. In Studien zur Frontzahnversorgung liegt die Implantatprognose für ältere Erwachsene eher noch höher, aber auch hier kann es zu Infraokklusionen von im Schnitt 0,3 mm und im Einzelfall über 1 mm kommen. Daher werden Implantate nicht zum Einzelzahnersatz in der Zahnreihe bei Kindern empfohlen, hier kommt eine Implantatversorgung eher bei schweren Hypodontien oder Anodontien infrage. Bei Adoleszenten sollte die tradierte harte Grenze des 18. Lebensjahrs eher einer differenzierten Bewertung weichen und ersetzt werden durch das Abwarten des pubertären Wachstumsspurts. Die sicher auftretende Infraokklusion sollte aber therapeutisch antizipiert und wie die etwas reduzierte Implantatprognose den Patienten und Eltern mitgeteilt werden. Auch nach dem 18. Lebensjahr kommt es zu Infraokklusionen, worüber der Patient aufgeklärt werden sollten. Keywords: Infraokklusion, Kinder, Adoleszenten, Implantatüberleben, Ankylose, Wachstum, Kieferentwicklung
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Deutsche Zahnärztliche Zeitschrift, 2/2016
BuchneuvorstellungenDOI: 10.3238/dzz.2016.0124Language: GermanSanz, Mariano / Stadlinger, Bernd / Terheyden, Hendrik / Herring, Susan W.

Buchneuerscheinungen

Quintessenz, Berlin 2016, DVD, ISBN 978-3-86867-301-2, 98,00 Euro Keywords: Aphthen, aphthöse Läsionen, Morbus Behçet, orale Ulzerationen, genitale Ulzerationen, Therapie
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Implantologie, 2/2014
Pages 119-120, Language: GermanTerheyden, Hendrik

Editorial: Prothetische oder autologe Rekonstruktion bei Alveolarkammdefekten?

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International Poster Journal of Dentistry and Oral Medicine, 5/2013
SupplementPoster 679, Language: EnglishMöller, Björn / Acil, Yahya / Gierloff, Christine / Terheyden, Hendrik / Wiltfang, Jörg

Prefabrication of vascularised 3-D bone flaps with different growth factors in the great omentum in rabbits for reconstruction of large bony defects

Objectives: Reconstruction of bony defects can be done by free flaps. Donor site morbidity and misfit of the shape are limiting factors. The concept of using the patient as bioreactor solved many problems. The aim of the study was to evaluate if the great omentum is a capable anatomical site for prefabrication. Methods: In each of 30 adult male New Zealand white rabbits (4.0kg) 2 blocks of biomaterial were implanted in the great omentum with a central vascular pedicle in a cavity of the scaffold. The following five groups were created according to the biomaterial: (1) Bio-Oss® Block, (2) Bio-Oss® Block + rhBMP-2, (3) Bio-Oss® Block + rhBMP-2 + VEGF-165 (4) Bio-Oss® Block + autologous bone, (5) Bio-Oss® Block + autologous bone + rhBMP-2. CT examinations were performed after the implantation and 2, 4, 6 and 10 weeks later to define the bone density. The animals were sacrificed at 10 weeks postsurgery after intraperitoneal injection of fluorochromes and the specimens were collected for histological, immunohistochemical and histomorphometric analysis. Results: First analyses could show that the great omentum has advantage among other sites previously described with a long vascular pedicle, less postoperative functional impairment and more flexibility. The central blood vessel in the center of the scaffold resembles the natural anatomy of the mandible and other bones with a marrow cavity and enhances the ossification. The bone density increases particularly with the use of BMP-2 and VEGF-165 and has the highest values with additional use of autologous bone (HU: average between 483 (BioOss-Block alone) and 1054 (+ autologous bone with BMP-2). The floureszenz staining shows ossification also with BMP alone. Also the toluidine blue and HE staining shows ossifcation and development of new vessels in the scafold. There are indications that the efficacy of the dosage could be enhanced by addition of VEGF-165. Conclusions: We could demonstrate for the first time that the great omentum is a capable new anatomical site for prefabrication. It can be used as a bioreactor in vivo for prefabrication tissue-engineered bone. Prefabrication in the great omentum may go from bench to bedside and will show effectiveness in mandibular reconstruction. Keywords: prefabrication, omentum majus, reconstruction, bmp, vegf
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The International Journal of Oral & Maxillofacial Implants, 4/2013
DOI: 10.11607/jomi.2594, PubMed ID (PMID): 23869355Pages 982-988, Language: EnglishWarnke, Patrick H. / Voss, Eske / Russo, Paul A. J. / Stephens, Sebastien / Kleine, Michael / Terheyden, Hendrik / Liu, Qin

Antimicrobial Peptide Coating of Dental Implants: Biocompatibility Assessment of Recombinant Human Beta Defensin-2 for Human Cells

Purpose: Artificial materials such as dental implants are at risk of bacterial contamination in the oral cavity. Human beta defensins (HBDs), small cationic antimicrobial peptides that exert a broad-spectrum antibacterial function at epithelial surfaces and within some mesenchymal tissues, could probably help to reduce such contamination. HBDs also have protective immunomodulatory effects and have been reported to promote bone remodeling. The aim of this study, therefore, was to investigate the influence of recombinant HBD-2 on the proliferation and survival of cells in culture. Materials and Methods: Human mesenchymal stem cells (hMSCs), human osteoblasts, human keratinocytes (control), and the HeLa cancer cell line (control) were incubated with recombinant HBD-2 (1, 5, 10, or 20 µg/mL). Cell proliferation and cytotoxicity were evaluated via a water-soluble tetrazolium salt (WST-1) and lactate dehydrogenase assays, respectively. Results: HBD-2 was not toxic in any tested concentration to hMSCs, osteoblasts, keratinocytes, or HeLa cells. Furthermore, proliferation of hMSCs and osteoblasts increased after treatment with HBD-2 at all tested concentrations, and keratinocyte proliferation increased when treated at 20 µg/mL. In contrast, HeLa cancer cells were not affected by HBD-2 as tested. Conclusions: HBD-2 is not only biocompatible but also promotes proliferation of hMSCs, osteoblasts, and keratinocytes in culture. Further investigation of HBD-2 functional surface coating of artificial materials is recommended. Keywords: antimicrobial peptides, biocompatibility, human beta defensins, human mesenchymal stem cells, human primary osteoblasts, implant dentistry
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Implantologie, 2/2013
Pages 127-128, Language: GermanTerheyden, Hendrik

Editorial: Weichteilmanagement - eine Investition in die Zukunft

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