Within the context of professional prevention, biofilm should be removed as completely and as gently as possible. This is achieved with a systematic clinical protocol and with instruments and materials according to current state-of-the-art practice, science, and technology. This paper focuses on the chemical, physical and clinical characteristics of powder products used for air-water-powder devices in the context of professional prophylaxis protocols. “Air flowing” is a technically highly advanced version of this concept which has been documented in studies. This consists of the effective and tissue-sparing use of an optimized powder with compatible devices and instruments. It forms part of the “Guided Biofilm Therapy” (GBT), a modular and systematic clinical protocol from EMS (Nyon, Switzerland) for primary, secondary, and tertiary prevention.