Purpose: The objective of this systematic review and meta-analysis was to examine the impact of

titanium base supported single implant restorations on peri-implant conditions. Materials and

Methods: Six randomized controlled trials (RCTs), comprising a total of 274 implants that met the

inclusion criteria, were chosen for data analysis. A random effects model was employed for the metaanalysis.

Results: Data from this study revealed that the Ti-base group exhibited a slightly but

statistically significant increase in peri-implant marginal bone loss (difference in means = 0.088, 95%

confidence interval = 0.003 to 0.17, p = 0.041) compared to the one-piece-abutment group. These

effects were consistent in the subgroup analysis of regular-threaded implants comparing to the microthreaded

subgroup. However, no significant differences were observed between the Ti-base group and

the abutment group concerning probing depth (PD), bleeding on probing (BOP), and the risk of

prosthetic-related complications. Conclusions: The utilization of Ti-base in single-implant supported

restoration is associated with a slight increase in peri-implant marginal bone loss, while other periimplant

health parameters show no significant correlation. Therefore, to determine the impact of Tibase

on peri-implant condition of single implant-supported restoration is insufficient based on the

findings of this meta-analysis.