Purpose: The successful osseointegration around immediate implants requires high
quality and quantity of osteogenesis around them. The role of magnesium as a boneenhancing
mineral, and as an adjunctive analgesic has been well documented in
orthopedic literature. However, there is a paucity of literature in its role in successful
osseointegration around immediate implants. This randomized controlled trial sought to
assess the promising impact of magnesium on osseointegration by examining various
aspects of implant stability, correlating them with serum bone markers, and establishing
a foundation for future research on its potential as a potent analgesic. Materials and
Methods: Immediate implant placement was done after the extraction of the indicated
mandibular molar tooth, and all the patients were segregated into 2 groups (Placebo-
Lactose, and Magnesium citrate). Bone regenerate in the peri-implant area was assessed
radiographically immediate post-operatively, on the 6th week and 12 weeks. Implant
stability was measured immediate post-operatively, at the 4th week and 12th week.
Serum parameters were procured pre-operatively and post-operatively for serum
calcium, serum alkaline phosphatase (ALP), and serum parathyroid hormone at the 8th
week, and serum vitamin D3 levels preoperatively. Results: 54 immediate implants
placed showed the demographics and baseline serum, clinical, and radiographic
parameters were comparable in both groups. Analysis of Implant Stability Quotient at
12th week showed statistically significant difference in intervention group both on
intergroup and intragroup analysis. Radiodensity measurement showed a statistically
significant difference in both intragroup and intergroup analysis in the intervention
group at the 6th and 12th week. In bone gap analysis, the difference in mean change in
the horizontal bone gap (HG) at 6 weeks was non-significant while the difference in
HG at the 12th week was significant in the intervention group. On intragroup analysis,
mean change HG at 6 weeks and 12 weeks both were significant only in intervention
group. Intergroup analysis of vertical bone gap (VG) 12 and VG 12-0 (mean difference
in the vertical bone gap from 12th week-day 0) showed a statistically significant
difference in the intervention group. On intragroup analysis, VG 12 was significantly
better in the intervention group. On serum analysis, ALP post-operatively was found to
be significantly raised (P=0.013) in intervention group. Numerical rating Scale (NRS)
analysis showed a significant decrease in post-op day 5 and 7, (P=0.017) and (P=0.002)
respectively. Conclusion: The oral magnesium citrate supplementation after immediate
implant placement helps in enhancing the stability of the immediate implants, along
with improved radiodensity around them which was found to be statistically significant.
It also helps in reducing the horizontal, and vertical gap around the implant and has
significant analgesic potential.
Schlagwörter: Immediate implant; Magnesium citrate; Implant stability quotient; Analgesia; Osseointegration