The Michigan Computer Graphics Coordinate Measurement System was used to measure the wear of three composite resins and an amalgam alloy control. The validity of the Latin Square experimental design for analysis in a clinical study was demonstrated, and statistically significant differences in wear were established for main effect for the materials under investigation. None of the composite resins examined approximated the amalgam alloy control in wear properties. Rank ordering of the materials with respect to wear was possible using this experimental design. Ranking of the materials for wear resistance using this research approach opens up other future research opportunities to correlate such properties as filler particle size, composition, and distribution with the data derived.