PURPOSE: The purpose of this study was to evaluate both marginal and overall adaptation of 4 adhesively luted ceramic inlay systems. MATERIALS AND METHODS: A total of 40 extracted teeth were restored with mesio-occlusodistal ceramic inlays using 4 different techniques: Colorlogic, IPS Empress, Celay direct, and Celay indirect. After cementation with a resin luting agent, the samples were sectioned along a mesiodistal line passing through the center of the restoration. The thickness of the cement was measured at the margins and at several points along the inside of the restorations by means of a stereomicroscope fitted with a measuring grid. RESULTS: The results were analyzed by one-way analysis of variance. The marginal precision of IPS Empress and Colorlogic inlays averaged below 50 microns. Marginal precision of Celay inlays averaged between 110 and 130 microns. IPS Empress and Celay inlays showed a uniform distribution of the cement along the entire prepared surface. Colorlogic inlays showed an uneven distribution of the cement film. CONCLUSION: IPS Empress inlays showed the best clinical features compared to Colorlogic and Celay inlays.