Purpose: The aim of this study was to determine whether a condition similar to Combination Syndrome occurs in patients rehabilitated with a maxillary complete denture opposing a mandibular implant-supported fixed prosthesis. Materials and Methods: Standardized clinical procedures measured fit, occlusal integrity, and bone loss in the anterior maxilla in 11 edentulous subjects meeting these requirements, from the patient pool of the Implant Centre, United Dental Hospital, Sydney. Results: A mean annual loss of 0.17 mm in the anterior maxillary ridge height was not statistically significant (P > 0.05). However, increased pressure in the anterior maxillary ridge during occlusion and loss of posterior occlusal contacts in retruded position were noted on one or both sides in all subjects. Conclusion: Loss of posterior occlusion could not be related to anterior maxillary bone loss. However, to maintain the integrity of the prostheses and their supporting structures, it is important to schedule periodic recall appointments for review of the occlusion.