The purpose of this study was to evaluate the occlusion of all-ceramic onlay surfaces generated with a laboratory (LAB) and computer-aided design/computer-assisted manufacturing (COMP) system. The treatment of the mandibular left first molar was simulated on 16 casts. A minimum of three static contacts and their localization were defined beforehand (MIN3). The occlusal contacts obtained (CORR) were analyzed and the mean quotients (MIN3/CORR) for COMP- and LAB-processed restorations were calculated (1.06 ± 0.17 and 1.03 ± 0.13, respectively). The Wilcoxon signed ranks test revealed no significant differences (P .05).