Implant guide systems can be classified by their supporting structure as tooth-, mucosa-, or bone-supported. Mucosa-supported guides for fully edentulous arches show lower accuracy in implant placement because of errors in image registration and guide positioning. This article introduces the application of a novel microscrew system for computeraided implant surgery. This technique can markedly improve the accuracy of computerguided implant surgery in fully edentulous arches by eliminating errors from image fusion and guide positioning.