Purpose: To evaluate the precision and trueness of computerized optical impressions of maxillectomy defects. Materials and Methods: Three different maxillectomy defect models based on the Aramany classification system were used. Reference digitization of the models was performed with an industrial computerized tomography scanner. Each model was scanned five times using an intraoral scanner (True Definition). With the use of 3D evaluation software, the 3D datasets were geometrically superimposed using a best-fit algorithm to evaluate precision and trueness. Statistical analysis was performed to determine differences between the scans. Results: There was a statistically significant difference in both precision and trueness between Aramany classes (P .001). Conclusion: Digitizing maxillectomy defect models with an intraoral scanner appears to be accurate and reliable.