Purpose: To analyze the clinical behavior of screw-retained monolithic lithium disilicate (LDS) implantsupported single crowns (ISSCs) over a 1-year follow-up. Materials and Methods: A total of 28 patients were restored with 45 screw-retained monolithic LDS (press-fabricated) ISSCs bonded to titanium bases in posterior sites. Modified United States Public Health Service criteria and Kaplan-Meier survival and success rates were evaluated. Results: A total of 27 patients with 44 ISSCs were evaluated 12 months (mean ± standard deviation: 13.02 ± 2.28) after prosthesis delivery. No implant or crown failures occurred. The Kaplan-Meier survival and success rates were each 100% after 1 year. Minorly increased surface roughness was noted in the occlusal contact point areas of 9 ISSCs (20.5% Bravo rating). Marginal adaptation, color match, and anatomical form stayed favorable over time. Conclusion: Press-fabricated LDS monolithic screwretained implant crowns appear to be a promising treatment option for posterior implants under short-term observation.