Purpose: To assess the feasibility of using an intraoral scanner for data acquisition of maxillectomy defects. Materials and Methods: In 10 patients who had undergone a maxillectomy, the maxillectomy defects in dentate and edentulous maxillary arches were intraorally scanned. Intraoral photographs were also taken using a digital camera for comparison. Results: Adequate scanning was achieved for the nondefect side of the maxilla and for residual teeth. In some cases, it was impossible to scan the maxillectomy defect, especially the deep sites. Conclusion: Improved intraoral scanning technology will increase the feasibility of its use in maxillofacial prosthetics.