Purpose: To establish the most effective cementation protocol for bonding zirconia crowns to Ti-Base CAD/CAM abutments in terms of abutment height, cement type, and surface pretreatment. Materials and Methods: Zirconia crowns were designed to fit abutments of 2.5-mm (short) and 4.0-mm (tall) height. The retention of conventional resin cement with a universal adhesive (RelyX Ultimate, 3M ESPE) was compared to self-adhesive resin cement (RelyX U200, 3M ESPE) following different surface pretreatments (n = 10/ group): (1) no treatment (NT); (2) Ti-Base abutment surface blasting with alumina particles (SB); (3) zirconia crown tribochemical surface blasting with silica-coated alumina particles (TBS); and (4) a combination of SB + TBS. Pull-out testing was performed in a universal testing machine. Data were statistically evaluated using a linear mixed model following least significant difference post hoc test. Results: Pull-out data as a function of Ti-Base height demonstrated higher retention for tall compared to short abutments (P .001). Ultimate outperformed U200 cement (data collapsed over height and pretreatment) (P .001). Analysis of pretreatment depicted higher retention for SB + TBS, followed by SB, TBS, and NT (P .04). The interaction between Ti-Base height and cement type highlighted the superior adhesive strength of Ultimate compared to U200 for both heights (P .001). Irrespective of type of pretreatment, surface pretreatment improved the retention for U200 cement and short Ti-Base (P .03 compared to NT). In contrast, higher retention was demonstrated for SB + TBS, followed by SB, TBS, and NT, for Ultimate cement combined with tall Ti-Base (P .02) (data collapsed over height and cement, respectively). Conclusion: There was a direct relationship among Ti-Base height, micromechanical and/or chemical pretreatment, and conventional adhesive bonding in improving the retention of zirconia crowns.