The digital workflow - from the intraoral scanning, through the CAD design of the facially generated diagnostic digital wax-up, to the CAD-designed and 3D-printed silicone index with the diagnostic mock-up - provides a new approach that avoids the conventional manufacturing of casts. The development of the process requires a synchronized workflow and good communication between the dental technician, prosthodontist, and patient. This report describes a protocol for the diagnostic digital sequence for the treatment planning of an esthetic rehabilitation.