This study examines a protocol for achieving successful osseointegration in immediately loaded implants. With an atraumatic surgical technique and an acceptable biomaterial for implant placement, in certain cases adequate splinting of implants may sufficiently shield the bone-implant interface from functional overload and prevent micromovement from exceeding the allowable limits for successful osseointegration. Two successful cases are presented in which titanium root-form implants were immediately loaded for the support of fixed restorations in the maxilla and the mandible. The authors conclude that for a distinct patient population, immediate loading of multiple, splinted implants may prove to be a valuable adjunct to therapy.