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PD Dr. Matthias Widbiller received his degree in dentistry from the University of Regensburg in the year 2013. He immediately joined the Department of Conservative Dentistry and Periodontology at the University Hospital Regensburg as dentist and research fellow and did his doctorate in 2015. Matthias Widbiller is university lecturer for conservative dentistry and directing a patient course in this subject. From 2017 to 2018, he received a post-doctoral training at the University of Texas Health Science Center at San Antonio (UTHSCSA) in the research lab of Dr. Kenneth M. Hargreaves and Dr. Anibal Diogenes. His areas of research include dental pulp tissue engineering, bioactive materials and bioactive proteins of the dentin matrix. He was habilitated by the faculty of medicine at the University of Regensburg in 2019.
8. Nov 2019 — 9. Nov 2019Congress Center Messe Frankfurt
Speakers: Karl-Ludwig Ackermann, Sarah Al-Maawi, Kurt Werner Alt, Jassin Arnold, Thomas Attin, Mustafa Ayna, Anna Greta Barbe, Ingo Baresel, Jens Baresel, Tobias Bauer, Ursula Becker, Wilfried Beckmann, Christoph Benz, Lisa Bitterich, Dirk Bleiel, Uwe Blunck, Martin Boost, Andreas Braun, Anne Bredel-Geissler, Wolfgang Buchalla, Egon Burian, Sebastian Bürklein, Iain L. C. Chapple, Wolfgang Christian, Fabian Cieplik, Bettina Dannewitz, Monika Daubländer, Sybille David-Hebgen, Isabel Deckwer, James Deschner, Annika Döding, Christof Dörfer, Heike Dyrna, Norbert Engel, Peter Engel, Susanne Fath, Michael Frank, Roland Frankenberger, Rene Franzen, Cornelia Frese, Tobias Fretwurst, Michael Gahlert, Roland Garve, Werner Geurtsen, Shahram Ghanaati, Christiane Gleissner, Ulrike Gonder, Werner Götz, Dominik Groß, Knut A. Grötz, Martin Guffart, Norbert Gutknecht, Cornelius Haffner, Thorsten Halling, Frederic Hermann, Carlos Herrera-Vizcaino, Tim Hilgenfeld, Jürgen Hoffmann, Martin Hoffmann, Fabian Huettig, Alfons Hugger, Christine Hutschenreuter, Bruno Imhoff, Silke Jacker-Guhr, Søren Jepsen, A. Rainer Jordan, Alexander Jürchott, Bärbel Kahl-Nieke, Peer W. Kämmerer, Philipp Kanzow, Nele Kettler, Christian Kirschneck, Lydia Kogler, Bernd Kordaß, Franz-Josef Kramer, Norbert Krämer, Felix Krause, Matthis Krischel, Joachim Krois, Christina Kühne, Conrad Kühnöl, Bernd Lapatki, Silke Lehmann-Binder M.Sc., Christian Leonhardt, Ivona Leventic, Daniel Lindel, Jörg Alexander Lisson, Ulrike Lübbert, Elmar Ludwig, Anne-Katrin Lührs, Michael Lüpke, Frank Georg Mathers, Wibke Merten, Georg Meyer, Wolfram Misselwitz, Karin Mölling, Mhd Said Mourad, Dietmar Friedrich Müller, Moritz Mutschler, Katja Nickel, Nicole Nicklisch, Ina Nitschke, Olaf Oberhofer, Karina Obreja, Dietmar Oesterreich, Rebecca Otto, Simon Peroz, Peter Pospiech, Florian Probst, Monika Probst, Michael Rädel, Sven Reich, Katharina Reichenmiller, Katharina Reinecke, Daniel R. Reißmann, Bernd Reiss, Stefan Ries, Christiane Rinnen, Katharina Röher, Jerome Rotgans, Uwe Rudol, Sebastian Ruge, Michael Rumpf, Heidrun Schaaf, Claudia Schaller, Karina Schick, Ulrich Schiffner, Maximiliane Amelie Schlenz, Alexander Schmidt, Mathias Schmidt, Andrea-Maria Schmidt-Westhausen, Julian Schmoeckel, Wolfgang Schneider, Sigmar Schnutenhaus, Holger Schön, Andreas Schulte, Nelly Schulz-Weidner, Karola Schulze, Ralf Schulze, Falk Schwendicke, Thomas A. Schwenk, Andreas Simka, Ralf Smeets, Önder Solakoglu, David Sonntag, Hansmartin Spatzier, Benedikt Spies, Norbert Staab, Sabine Steding, Angela Stillhart, Marcus Stoetzer, Hendrik Terheyden, Andrea Thumeyer, Marin Vodanovic, Kai Voß, Maximilian Voß, Wolfgang Wahlster, Michael Walter, Sandra Weber, Almut Johanna Weigel, Paul Weigl, Michael Weiss, Hans-Jürgen Wenz, Johannes-Simon Wenzler, Christian Wesemann, Jens Westemeier, Lotta Westphal, Matthias Widbiller, Annette Wiegand, Horst Willeweit, Karl Frederick Wilms, Sandra Windecker, Michael M. Wolf, Anne Wolowski, Bernd Wöstmann, Sylvia Wuttig
Quintessenz Verlags-GmbH
This author's journal articles
Oral Health and Preventive Dentistry, 1/2022
Open Access Online OnlyOral HealthDOI: 10.3290/j.ohpd.b2831749, PubMed ID (PMID): 3530801621. Mar 2022,Pages 149-156, Language: EnglishSchmalz, Gottfried / Widbiller, Matthias
Summary: The Minamata Convention resulted in restrictions in the use of amalgam in daily dental practice. This opens up new discussions about the biocompatibility of amalgam, but also of composites as alternative materials. In the following review article, these issues will be discussed in more detail to provide dentists with a knowledge base for themselves and for communication with their patients. In addition to mercury in amalgam or monomers in composites, bisphenol A and nanoparticles generated during the grinding, polishing or removal of restorations must also be included in the biocompatibility evaluation. In laboratory tests, these substances cause toxic reactions, and bisphenol A also exhibits estrogen-like effects. However, it must be taken into account that the concentrations used in laboratory tests are much higher than in clinical practice. Thus, both amalgam and composite can be used in the general population. Nevertheless, for scientifically, politically and legally defined risk groups (e.g. dental personnel, allergic persons, pregnant or lactating women, children under 15 years of age, people with certain systemic diseases), indication restrictions and precautionary measures must be observed. The well-known amalgam discussion has taught us the importance of thorough and open risk communication with the patient.
Keywords: bisphenol-A, child, lactation, mercury, pregnancy
Neben dem Quecksilber aus Amalgam oder den Monomeren aus Kompositen müssen heute auch Bisphenol A und Nanopartikel, welche beim Beschleifen, Polieren oder Entfernen von Restaurationen entstehen, in die Bewertung der Biokompatibilität einbezogen werden. In Laborversuchen rufen diese Substanzen toxische Reaktionen hervor und Bisphenol A zeigt zudem eine östrogenartige Wirkung. Allerdings sind die applizierten Konzentrationen in Laboruntersuchungen wesentlich höher als im klinischen Alltag. Deshalb können sowohl Amalgam als auch Komposit bei der Allgemeinbevölkerung eingesetzt werden. Hingegen sind bei wissenschaftlich und politisch definierten Risikogruppen (zahnärztliches Personal, Allergiker, Schwangere bzw. Stillende, Kinder unter 15 Jahren, Menschen mit speziellen Allgemeinerkrankungen) Indikationseinschränkungen und Vorsichtsmaßnahmen zu beachten. Die bekannte Amalgamdiskussion hat uns dabei die Bedeutung einer eingehenden und offenen Risikokommunikation mit dem Patienten gelehrt.
Neben dem Quecksilber aus Amalgam oder den Monomeren aus Kompositen müssen heute auch Bisphenol A und Nanopartikel, welche beim Beschleifen, Polieren oder Entfernen von Restaurationen entstehen, in die Bewertung der Biokompatibilität einbezogen werden. In Laborversuchen rufen diese Substanzen toxische Reaktionen hervor, und Bisphenol A zeigt zudem eine östrogenartige Wirkung. Allerdings sind die applizierten Konzentrationen in Laboruntersuchungen wesentlich höher als im klinischen Alltag. Deshalb können sowohl Amalgam als auch Komposit bei der Allgemeinbevölkerung eingesetzt werden. Hingegen sind bei wissenschaftlich und politisch definierten Risikogruppen (zahnärztliches Personal, Allergiker, Schwangere bzw. Stillende, Kinder unter 15 Jahren, Menschen mit speziellen Allgemeinerkrankungen) Indikationseinschränkungen und Vorsichtsmaßnahmen zu beachten. Die bekannte Amalgamdiskussion hat uns dabei die Bedeutung einer eingehenden und offenen Risikokommunikation mit dem Patienten gelehrt.
Keywords: Amalgam, Komposit, Bisphenol A, Nanopartikel, Biokompatibilität, Risikogruppen
During tooth development odontoblasts embed growth factors in the dentin matrix, where their potential for biochemical signaling is preserved. They can be liberated later by demineralising agents and might influence immune response as well as the behavior of pulp cells. The aim of this study was to investigate the impact of dentin matrix proteins (DMPs) on the migration, viability and mineralisation of human dental pulp cells.
At first, a complex procedure to isolate, purify and concentrate DMPs (up to 80,000 pg/ml TGF-β1) from human dentin was established. DMPs were utilised at different concentrations in a modified Boyden chamber assay to investigate chemotactic effects on pulp cells after 24 hours. Viability was analysed by MTT testing over a period of 14 days, and alizarin staining after 21 days provided information on the induction of mineralisation.
DMPs showed a concentration-dependent chemotactic effect on human pulp cells and were able to influence their metabolic activity. Furthermore, they induced mineralisation that indicated cellular differentiation.
These investigations show the potential of endogenous signaling molecules from human dentin to influence viability and enhance the migration as well as differentiation of pulp cells. The release of DMPs, which is easy to achieve in the clinic through the superficial demineralisation of dentin, might optimise procedures in vital pulp therapy as well as in regenerative endodontics in the near future.
Keywords: dental pulp cells, dentin, EDTA, growth factors, regenerative endodontics